https://m.x-mol.com/paper/1399503044297080832/t?recommendPaper=1399502945462501376
Rebecca Winzeler, Patrice Max Ambühl
背景和目的 COVID-19 是一种传染病，可能由新型冠状病毒 SARS-CoV-2 感染引起。该病于 2019 年底在武汉首次发现，瑞士于 2020 年 2 月发现首例病例。该分析概述了瑞士经检测 COVID-19 呈阳性的透析患者。方法 所有透析中心都向瑞士透析登记处 srrqap 报告了他们的 COVID-19 病例。在 3 月 5 日（第 1 名 COVID-19 透析患者）至 2020 年 6 月 30 日期间向登记处报告的所有患者均纳入本分析，并与无 COVID-19 的透析患者（自 2019 年起）进行了比较。结果 2020 年 3 月 5 日，提契诺州首例透析患者感染了 COVID-19。3 月和 4 月，受感染的透析患者人数迅速增加，沃州 (23.5%)、提契诺州 (22.3%) 和日内瓦 (18.8%) 的大多数患者，加起来占瑞士 COVID-19 感染透析患者的近 65%。COVID-19 病例占所有接受透析的流行患者的 2.4%（截至 2019 年 12 月 31 日）。93 名透析患者中有 27 名（12 名女性，15 名男性）死亡，相当于 29% 的死亡率。瑞士（包括荷兰）患者的死亡率最高，罗马尼亚最低，为 8.5%（K. Jager 和 A. Kramer，2020 年提交出版）。死亡率与透析患者的高龄有关。与一般人群相比，男性、糖尿病和高血压不是我们队列中死亡的主要危险因素。结论 尽管与其他欧洲国家的透析患者相比，瑞士的透析患者总体上具有更好的生存率，但与其他欧洲国家相比，该人群中瑞士感染 COVID-19 的死亡率最高。此外，在我们的透析人群中，男性、糖尿病和高血压似乎不是相关的危险因素。
Background and Aims COVID-19 is an infectious disease that can result from infection with the novel coronavirus SARS-CoV-2. The disease, was first described in Wuhan at the end of 2019 and the first case in Switzerland was discovered in February 2020. This analysis gives an overview of dialysis patients in Switzerland that were tested COVID-19 positive. Method All dialysis centers reported their cases with COVID-19 to the Swiss dialysis registry srrqap. All patients reported to the registry between March 5 (1st dialysis patient with COVID-19) and June 30, 2020 were included in this analysis and comparisons were made with COVID-19-free dialysis patients (from 2019). Results On March 5, 2020, the first dialysis patient was infected with COVID-19 in Ticino. The number of infected dialysis patients increased rapidly over the months of March and April, with the majority of patients in the cantons of Vaud (23.5%), Ticino (22.3%) and Geneva (18.8%) and together making up almost 65% of the COVID-19-infected dialysis patients in Switzerland. COVID-19 cases represented 2.4% of all prevalent patients on dialysis (as of 31.12.2019). Twenty-seven (12 female, 15 male) out of 93 dialysis patients died, which corresponds to a mortality rate of 29%. Mortality was highest in patients from Switzerland (together with the Netherlands), and lowest in Romania with 8.5% (K. Jager and A. Kramer, submitted for publication, 2020). Mortality was associated with advanced age in dialysis patients. In contrast to the general population, male sex, diabetes and hypertension were no major risk factors for mortality in our cohort. Conclusion Although dialysis patients from Switzerland in general have a better survival compared to those from other European countries, infection with COVID-19 in Switzerland results in the highest mortality compared to other European countries in this population. In addition, male sex, diabetes and hypertension seem not to be associated risk factors in our dialysis population.